eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
1/2024
vol. 41
 
Share:
Share:
abstract:
Original paper

Long-term efficacy, safety, and drug survival of secukinumab in patients with psoriasis in Turkey: a retrospective analysis of real-world experience

Fatma Elif Yıldırım
1
,
Fatma Aslı Hapa

  1. Department of Dermatology, Faculty of Medicine, Sanko University, Gaziantep, Turkey
Adv Dermatol Allergol 2024; XLI (1): 49-55
Online publish date: 2024/03/15
View full text Get citation
 
Introduction:
Secukinumab (SEC) has been shown to be highly effective and safe in the treatment of moderate to severe plaque psoriasis (PsO), but data on SEC’s long-term drug survival are limited.

Aim:
To analyse the survival rate of SEC and its predictive factors of survival, together with the drug safety and efficacy.

Material and methods:
Data of 268 patients who received SEC between May 2018 and April 2022 with moderate to severe psoriasis and/or psoriatic arthritis were analysed retrospectively. Psoriasis Area Severity Index (PASI) was used to define effectiveness. Drug survival was examined using the Kaplan-Meier analysis and Cox regression analysis was used to analyse predictive factors.

Results:
PASI 75/90/100 responses achieved at week 16 (89.5%, 78%, and 16.2%, respectively) were well maintained at week 52 (96.3%, 90.7%, and 15.4%, respectively). The drug survival probability rates for SEC were 94.4% at 12 months, 88.4% at 24 months, 78.6% after 3 years, 52.7% after 4 years. Concomitant treatments, dose escalation and family history of psoriasis were associated with a higher risk for SEC withdrawal.

Conclusions:
Close monitoring may improve SEC survival in psoriasis patients who require dose escalation and concomitant drugs.

keywords:

psoriasis, secukinumab, biologics, daily clinical practice, drug survival

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.